Systems and Synthetic Biology Approaches to Engineer Fungi for Fine Chemical Production

Since the advent of systems and synthetic biology, many studies have sought to harness microbes as cell factories through genetic and metabolic engineering approaches. Yeast and filamentous fungi have been successfully harnessed to produce fine and high value-added chemical products. In this review, we present some of the most promising advances from recent years in the use of fungi for this purpose, focusing on the manipulation of fungal strains using systems and synthetic biology tools to improve metabolic flow and the flow of secondary metabolites by pathway redesign. We also review the roles of bioinformatics analysis and predictions in synthetic circuits, highlighting in silico systemic approaches to improve the efficiency of synthetic modules

The International Virus Bioinformatics Meeting 2023

The 2023 International Virus Bioinformatics Meeting was held in Valencia, Spain, from 24–26 May 2023, attracting approximately 180 participants worldwide. The primary objective of the conference was to establish a dynamic scientific environment conducive to discussion, collaboration, and the generation of novel research ideas. As the first in-person event following the SARS-CoV-2 pandemic, the meeting facilitated highly interactive exchanges among attendees. It served as a pivotal gathering for gaining insights into the current status of virus bioinformatics research and engaging with leading researchers and emerging scientists. The event comprised eight invited talks, 19 contributed talks, and 74 poster presentations across eleven sessions spanning three days. Topics covered included machine learning, bacteriophages, virus discovery, virus classification, virus visualization, viral infection, viromics, molecular epidemiology, phylodynamic analysis, RNA viruses, viral sequence analysis, viral surveillance, and metagenomics. This report provides rewritten abstracts of the presentations, a summary of the key research findings, and highlights shared during the meeting

The International Virus Bioinformatics Meeting 2023

Peer reviewed: TrueAcknowledgements: The conference organizers thank all speakers, poster presenters, chairs and participants for creating a highly interactive scientific environment and making the meeting a success. The conference organisers acknowledge sponsorship from Promega Biotech Ibérica SL. We thank Milena Žarković, Ruben Rose, Christina Martínez Christophersen, Lea Paltzow, Mohsen M. Hegab, Anna Wansorra, Akash Srivastava, Andi Krumbholz, Pablo A. Gutiérrez, João M.F. Silva, Juan C. Muñoz-Sánchez, Maria J. Olmo-Uceda, José A. Oteo and Carlos P. Garay, Yanhua Xu, Dominik Wojtczak, Matthew Baylis, Joaquin Mould-Quevedo, Markus Braun, Gibran Rubio Quintanares, Pauline Santos, Erica Margiotta, Janice Brückmann, Csaba Miskey, Johannes Blümel, Renate König, Liam Childs, Frank O. Aylward, Alexander Lukashev, Artem Orlov, Celia Jakob, Hardin Bolte, Christian Höner zu Siederdissen, Martin Schwemmle.Funder: VirBio 01KI2106Funder: The Pandemic Institute & CSL Seqirus Influenza Research Partnership (LB)Funder: LPIThe 2023 International Virus Bioinformatics Meeting was held in Valencia, Spain, from 24–26 May 2023, attracting approximately 180 participants worldwide. The primary objective of the conference was to establish a dynamic scientific environment conducive to discussion, collaboration, and the generation of novel research ideas. As the first in-person event following the SARS-CoV-2 pandemic, the meeting facilitated highly interactive exchanges among attendees. It served as a pivotal gathering for gaining insights into the current status of virus bioinformatics research and engaging with leading researchers and emerging scientists. The event comprised eight invited talks, 19 contributed talks, and 74 poster presentations across eleven sessions spanning three days. Topics covered included machine learning, bacteriophages, virus discovery, virus classification, virus visualization, viral infection, viromics, molecular epidemiology, phylodynamic analysis, RNA viruses, viral sequence analysis, viral surveillance, and metagenomics. This report provides rewritten abstracts of the presentations, a summary of the key research findings, and highlights shared during the meeting